Inhibiting IGF-1 for osteoarthritis

Targeting cartilage IFG-1, an insulin-like growth hormone expressed downstream of WNT signaling, could help treat osteoarthritis by decreasing WNT hyperactivation-induced joint damage.

Genome-wide transcriptomic analysis of datasets from healthy human donor articular chondrocytes treated with a WNT hyperactivator tool compound, and of articular cartilage from a WNT gain-of-function mouse model, identified IGF-1 as the most upregulated gene when WNT was hyperactivated compared with normal WNT activation. ...