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ARTICLE | Distillery Therapeutics

GluK2 agonism for inflammatory skin diseases

January 28, 2025 12:51 AM UTC

Activating the glutamate receptor GluK2 could help treat inflammatory skin diseases by reducing mast cell expression of the activating receptor MRGPRX2, decreasing dermal mast cell proliferation and degranulation.

In a bioinformatic analysis of public data sets, GLUK2 was highly expressed in mast cells isolated from mouse skin, peritoneal cavities, palates, hearts, and fat. ...

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