GluK2 agonism for inflammatory skin diseases
Activating the glutamate receptor GluK2 could help treat inflammatory skin diseases by reducing mast cell expression of the activating receptor MRGPRX2, decreasing dermal mast cell proliferation and degranulation.
In a bioinformatic analysis of public data sets, GLUK2 was highly expressed in mast cells isolated from mouse skin, peritoneal cavities, palates, hearts, and fat. ...
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