Inhibiting EPCR or HO-1 for retinal neovascularization

Inhibiting the endothelial cell surface receptor EPCR or the activity of the heme catabolic enzyme HO-1, whose expression EPCR regulates, could help treat retinal neovascularization by decreasing pathological angiogenesis.

RNA sequencing and bioinformatic analysis of public data sets identified higher EPCR transcript expression in the retinas from mice with oxygen-induced retinopathy than in those from healthy controls. ...