ARTICLE | Distillery Therapeutics
Inhibiting cathepsin B for pulmonary fibrosis
February 27, 2025 2:15 AM UTC
Inhibiting the cysteine protease cathepsin B could help treat lung fibrosis by preventing the breakdown of the connective tissue that links the pleural membrane and the lung alveoli, and its movement into the deep lung tissue.
In patient lung samples and in multiple mouse models of lung fibrosis, connective tissue linking the pleural membrane and the lung alveoli was shown to break down and be transported into the lung tissue at the initiation of fibrosis. ...