OGT inhibition for endometrial cancer

Inhibiting the O-GlcNAc transferase OGT could help treat endometrial cancer by counteracting the pathological increase in O-GlcNAcylation that occurs upon tumor downregulation of the OGT-degrading E3 ubiquitin ligase complex component and tumor suppressor FBXO31, which leads to cancer cell de-differentiation and proliferation.

In a panel of 31 patient-derived endometrial tumor specimens, O-GlcNAcylation and OGT expression were increased compared with peritumoral control tissue. ...