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ARTICLE | Distillery Therapeutics

Blocking ITGB4 for Zika virus infection

BC Staff
April 1, 2025 3:39 AM UTC

Blocking the host integrin ITGB4 could help treat Zika virus infection by preventing the interaction between the plasma membrane protein’s extracellular domain and the Zika viral Env glycoprotein, thereby preventing viral host cell entry and infection.

Mass spectrometry-based screening of proteins from human epithelial cell lysates that bound to an isolated band of Zika virus Env identified ITGB4 as a host receptor for the viral protein. ...

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