Inhibiting HIF2A for idiopathic pulmonary fibrosis
Inhibiting the transcription factor HIF2A could help treat idiopathic pulmonary fibrosis by preventing the proliferation of pro-fibrotic epithelial cell populations in the lung, while promoting alveolar epithelial cell repair.
Bioinformatic analysis of public data sets identified higher HIF1A and HIF2A signaling in pro-fibrotic lung epithelial cells from pulmonary fibrosis patients than in those from individuals without pulmonary fibrosis. ...