Engineered IL33 protein for pancreatic cancer antitumor immunity

An optimized version of IL-33, a secreted cytokine that activates innate lymphoid cells to promote tertiary lymphoid structure (TLS) formation in tumors, could help treat pancreatic cancer by facilitating immune cells' tumor access and killing.

RNA sequencing of pancreatic cancer patient tumors identified IL33 as one of the most positively correlated genes with TLS gene signatures. Pancreatic cancer patient tumors with TLSs had higher IL-33 protein expression than tumors without TLSs, and higher IL-33 protein expression was associated with longer overall survival. ...