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ARTICLE | Distillery Therapeutics

Inhibiting CNDP2 to disrupt nutrient cooperativity in cancer

BC Staff
April 1, 2025 3:47 AM UTC

Inhibiting the secreted peptidase CNDP2 could help treat cancer by eliminating a cooperative cell survival mechanism that breaks down extracellular oligopeptides to release free glutamine, which is required for cell growth.

Assays measuring survival of a human melanoma cell line under different plating densities and nutrient levels showed cells grew in glutamine-deprived conditions only when densely plated, suggesting cooperative behavior. ...

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