Inhibiting SSAT activity for inflammatory skin diseases

Inhibiting the polyamine-regulating enzyme SSAT could help treat inflammatory skin diseases by blocking immunosuppressive Treg cells from undergoing a keratinocyte 4-1BBL-induced phenotypic switch to become inflammatory effector T cells.

SSAT protein expression was higher in skin Tregs from atopic dermatitis, cutaneous sarcoidosis, and psoriasis patients than in those from individuals without the diseases. In bioinformatic analyses of public data sets, SSAT expression was higher in skin Tregs from cutaneous sarcoidosis and psoriasis patients than in those from individuals without the diseases. ...