Action Required: Password Reset on Next Login

As part of our recent security and system improvements, a password reset will be required the next time you log in. This applies to username/password users only; SSO users are not affected.

To reset your password, please visit the Reset Password page.

We appreciate your patience during this transition and are available to assist with any questions. For support, please call us at +1 650-552-4224 or email us at support@biocentury.com.

BioCentury
ARTICLE | Clinical News

Gilead’s selonsertib fails Phase III for NASH compensated cirrhosis

February 12, 2019 12:01 AM UTC

Gilead Sciences Inc. (NASDAQ:GILD) said selonsertib (GS-4997) missed the primary endpoint in the Phase III STELLAR-4 trial to treat compensated cirrhosis due to non-alcoholic steatohepatitis (NASH). Selonsertib is an oral small molecule ASK1 inhibitor.

The primary endpoint measured the percent of patients who achieved a histologic improvement in fibrosis of at least one stage according to the NASH Clinical Research Network (CRN) classification without worsening of NASH after 48 weeks of treatment. Among 877 adults enrolled, 12.5% of patients that received 6 mg once-daily selonsertib (p=1) and 14.4% of patients dosed with 18 mg once-daily selonsertib achieved the endpoint vs. 12.8% of patients that received placebo...

Get Unlimited Access
Continue reading with a free trial.
Or Purchase This Article