HotSpot acquires Macroceutics for focused allosteric library

HotSpot is adding a key piece to its allosteric inhibitor platform through the acquisition of DNA-encoded library company Macroceutics: the technology to make chemical libraries tailored to allosteric, rather than active, sites.

The deal, announced Friday, could help HotSpot Therapeutics Inc. (Boston, Mass.) accelerate development timelines by improving the likelihood of finding hits and facilitating more iterations during lead optimization, co-founder and CSO Geraldine Harriman told BioCentury. Financial terms are undisclosed...