Inhibiting LIMA1 could treat hypercholesterolemia

A study published in Science from researchers at the Chinese Academy of Sciences suggested that inhibiting LIM domain and actin binding 1 (LIMA1; SREBP3) could reduce cholesterol absorption and help treat hypercholesterolemia.

High levels of LDL-C are a major risk factor for developing cardiovascular disease. While genetic factors are responsible for 40-50% of phenotypic variances in LDL-C, large-scale analyses have uncovered few genes influencing LDL-C...