Can exosomes step in as delivery vehicles where LNPs fall short?

BioCentury’s roundup of translational innovations also includes blood detection of pregnancy complications, BBB-crossing antibodies, and more

Six papers detail improved ways to degrade cell-surface cancer proteins through the lysosome

Together, blood-brain barrier transport technology and Phase I Alzheimer’s therapy drive rare 10-figure early-stage takeout

BioCentury’s roundup of translational innovations

Companies and academics showcase two approaches to make AAV capsids with enhanced brain targeting and suppressed liver targeting

At least seven companies aim to overcome the challenge of delivering an enzyme across the blood-brain barrier to treat MPS IIIA

Reagan-Udall Foundation meeting on biomarkers could change FDA policy on neuronal MPS endpoints, unleash approvals

Stacking up DYNE-251 against Sarepta’s Exondys and vesleteplirsen, and Avidity’s AOC 1001

Plus: Acelyrin says CRO Fortrea erred in psoriatic arthritis study, Aro raises $41.5M for tissue-targeted siRNA pipeline