BioCentury
ARTICLE | Product Development

Lead-212’s leading players

Decisions about manufacturing and distribution could be make-or-break for drug developers producing their own lead-212 

July 23, 2024 9:49 PM UTC

The four companies that have positioned themselves as lead-212 producers for their own pipelines are solving the isotope’s distribution challenges in different ways, undergirded by their respective manufacturing technologies. The key question is whether to decentralize, and how much.

While these companies are aligned on lead-212’s advantages over the higher-profile α particle-emitter actinium-225, they disagree on the question of how many manufacturing sites, and what types of technologies, are required to distribute the short-lived isotope effectively...